Leuprolide Acetate, a GnRH Agonist, Holds Up Neurodegeneration in an Experimental Glaucoma Model

CLINICAL PHARMACOLOGY Leuprolide acetate is a long-acting GnRH analog. A single monthly injection of LUPRON

The front chamber of LUPRON DEPOT 3.75 mg prefilled dual-chamber syringe contains leuprolide acetate (3.75 mg), purified gelatin (0.65 mg), DL-lactic and glycolic acids copolymer (33.1 mg), and D-mannitol (6.6 mg). The second chamber of diluent contains carboxymethylcellulose sodium (5 mg), D-mannitol (50 mg), polysorbate 80 (1 mg), water for injection, USP, and glacial acetic acid, USP to cont...

Microdose GnRH Agonist Flare-Up versus Ultrashort GnRH Agonist Combined with Fixed GnRH Antagonist in Poor Responders of Assisted Reproductive Techniques Cycles

Therapeutic Review Leuprolide Acetate

Leuprolide acetate is a potent Gonadotropin Releasing Hormone (GnRH) agonist. The general premise behind leuprolide is that it inhibits the synthesis of lutenizing hormone and follicle stimulating hormone via a negative feedback. By reducing the production of these hormones, the drug effectively reduces estrogen and androgen production. This compound has been formulated as a depot formulation (...

VASODILATOR EFFECTS OF THE β -AGONIST ISOPRENALINE IN AN EXPERIMENTAL MODEL OF HEART FAILURE

Heart failure is a clinical syndrome characterized by the inability of the heart to provide nutrient supply to tissues. In 75% of cases, the underlying pathology causing heart failure in patients with cardiac death is coronary heart disease. A rabbit model of heart failure with coronary ligation was produced to mimic coronary heart disease in humans. After producing the model, two arteries ...

Patterns of hormonal response to the GnRH agonist leuprolide in brothers of women with polycystic ovary syndrome: a pilot study.

BACKGROUND The aim of this study was to evaluate the effect of a single dose of leuprolide acetate on gonadotrophin and gonadal steroid secretion in brothers of women with polycystic ovary syndrome (PCOS), in order to assess P450c17alpha activity. An oral glucose tolerance test (OGTT) and a lipid profile were also performed. METHODS Twenty-two unrelated brothers of women with PCOS (PCOS(b)) a...